Department of Human Pathology University of Yamanashi

Department of Human Pathology University of Yamanashi

Department of Human Pathology University of Yamanashi

Tetsuo Kondo
Tetsuo Kondo

Professor
MD, PhD, FIAC

Kunio Mochizuki
Kunio Mochizuki

Associate Professor
MD, PhD

Naoki Oishi
Naoki Oishi

Senior Assistant Professor
MD, PhD

Tomohiro Inoue
Tomohiro Inoue

Assistant Professor
MD, PhD

Kazunari Kasai
Kazunari Kasai

Assistant Professor
MD

Toru Odate
Toru Odate

Research Assistant
Professor
MD

Masataka Kawai
Masataka Kawai

Clinical fellow
MD

Dignostic pathology is a clinical application of traditional anatomic pathology, contributing to determination of treatment strategy and evaluation of effects of treatment. We started as one of basic medical science departments at medical school in 1982. Subsequently, our department changed to clinical group in 2005 and now has been recognized as a laboratory of investigative pathology and clinical pathology. It is now responsible for all histological diagnosis of surgical specimens and autopsies at University Hospital as well as education of systemic pathology for undergraduate students. We are also actively doing molecular research in conjunction with diagnostic work. The partial details of our research are described as follows.

Research

In the field of endocrine pathology, we aim to clarify on the bases of molecular pathology and molecular cell biology, etiology, structure, histogenesis, course and outcome of endocrine disorders, particularly, the neoplasms of thyroid gland. Not only utilizing the pathological tissues from patients, tissues from animal experiments and cells from cell culture study consist of important part of the materials for our research, where, in addition to the molecular techniques, the latest technology of immunohistochemistry, immunoelectron microscopy, serial block-face SEM (SBF-SEM) and so on are routine use. The goal of our research is to contribute to the clinical medicine by improving diagnostic pathology and offering new principles for therapeutics as well.

  1. Normal thyroid
    1. 1) Histogenesis of thyroid follicles using chimera mice (EGFP/BALB/C)
      We demonstrated polyclonal origin of thyroid follicles
    2. 2) Function of thyroid follicles
      1. 1) Localization of Pendrin (apical location of novel iodide transporter)
      2. 2) TTF-1 (thyroid transcription facter-1) expression in C cells as well as follicular cells
      3. 3) Autoregulation mechanism of thyroid follicles
    3. 3) Autotransplantation of thyroid tissue in rats
  2. Neoplastic thyroid
    1. 1) Functional morphology of thyroid neoplasms evaluated by thyroid specific proteins (TTF-1 and so on) using immunohistochemical examination
      TTF-1 expression in medullary thyroid carcinoma and follicular cell tumors
    2. 2) Immunohistochemical analyses of nuclear proteins of papillary thyroid carcinoma cells
    3. 3) Genetic background of thyroid carcinomas
      1. 1) Expression and significance of Lunx family in thyroid carcinomas
      2. 2) Pediatric papillary and follicular thyroid carcinoma
      3. 3) Chromosome territory of thyroid cancer cells
      4. 4) Genetic landscape of poorly and undifferentiated thyroid carcinomas

Contact information

Department of Pathology, University of Yamanashi

1110 Shimokato Chuo Yamanashi 409-3898 Japan
TEL: +81-55-273-9529 (ext. 2272)
FAX: +81-55-273-9534
E-mail: