研究|山梨大学 医学部 人体病理学講座

山梨大学 医学部 人体病理学講座
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病理学的研究

Physician-scientistを目指して

人体病理学講座では病理診断業務と並行して、各種疾患の病因・病態の解明を目指した研究をしています。病理検体や培養細胞を用いた解析から新しい知見を発見し、かたちにすべく、日々努力しています。

甲状腺癌

甲状腺癌

甲状腺癌は内分泌臓器に発生する悪性腫瘍のなかでも頻度の高く、患者さんの数も世界的に増加しています。病理学的には、緩徐に進行し予後良好な乳頭癌、極めて悪性度の高い未分化癌、カルシトニンを産生する髄様癌とさまざまな組織型が存在します。人体病理学講座は開講以来、一貫して甲状腺癌の臨床病理学的・分子生物学的研究を主題とし、その成果を世界に向けて発信してきました。

現在は、以下の研究課題に取り組んでいます。

甲状腺癌のプログレッションにおけるTTF-1/NKX2.1の抑制機構の解明

Epigenetic silencing of TTF-1/NKX2.1 in thyroid carcinomas

甲状腺癌のプログレッションにおけるTTF-1/NKX2.1の抑制機構の解明
代表業績

Kondo T, Nakazawa T, Ma D, Niu D, Mochizuki K, Kawasaki T, Nakamura N, Yamane T, Kobayashi M, Katoh R. Epigenetic silencing of TTF-1/NKX2-1 through DNA hypermethylation and histone H3 modulation in thyroid carcinomas. Lab Invest. 2009 Jul;89(7):791-9.

甲状腺癌の浸潤におけるRUNX2の機能解明

Role of transcription factor RUNX2 in invasion of thyroid carcinomas

代表業績

Niu DF, Kondo T, Nakazawa T, Oishi N, Kawasaki T, Mochizuki K, Yamane T, Katoh R. Transcription factor Runx2 is a regulator of epithelial-mesenchymal transition and invasion in thyroid carcinomas. Lab Invest. 2012 Aug;92(8):1181-90.

小児・若年甲状腺癌の臨床病理学的・遺伝子学的特徴の解明

Clinicopathological and genetic features of pediatric thyroid carcinoma

代表業績

Oishi N, Kondo T, Nakazawa T, Mochizuki K, Inoue T, Kasai K, Tahara I, Yabuta T, Hirokawa M, Miyauchi A, Katoh R. Frequent BRAFV600E and absence of TERT promoter mutations characterize sporadic pediatric papillary thyroid carcinomas in Japan. Endocr Pathol. 2017 doi:10.1007/s12022-017-9470-y

甲状腺癌におけるTERTプロモーター変異の解析:特に未分化転化のリスク因子としての検討

TERT promoter mutation as a risk factor of anaplastic transformation in thyroid carcinoma

甲状腺癌におけるTERTプロモーター変異の解析:特に未分化転化のリスク因子としての検討
代表業績

Oishi N, Kondo T, Ebina A, Sato Y, Akaishi J, Hino R, Yamamoto N, Mochizuki K, Nakazawa T, Yokomichi H, Ito K, Ishikawa Y, Katoh R. Molecular alterations of coexisting thyroid papillary carcinoma and anaplastic carcinoma: identification of TERT mutation as an independent risk factor for transformation. Mod Pathol. 2017 Nov;30(11):1527-1537.

本邦におけるnon-invasive follicular tumor with papillary-like nuclei (NIFTP)の解析

Clinicopathological and genetic features of non-invasive follicular tumor with papillary-like nuclei (NIFTP)

Serial block-face scanning electron microscopy(SBF-SEM)による甲状腺乳頭癌の核形態の解析

Morphological analysis of nuclei of papillary thyroid carcinoma using serial block-face scanning electron microscopy(SBF-SEM)

Serial block-face scanning electron microscopy(SBF-SEM)による甲状腺乳頭癌の核形態の解析

消化管

消化器に発生する腫瘍の臨床(外科)病理学的研究

Pathological research of tumors in the digestive organs

消化器に発生する腫瘍の臨床(外科)病理学的研究
代表業績

Mochizuki K, Kondo T, Oishi N, Kawasaki T, Nakazawa T, Yamane T, Katoh R. Immature squamous metaplasia (focal atypical epithelial hyperplasia) of the pancreatic duct-immunohistochemical distinction from intraductal carcinoma. Histopathology. 2013 Sep;63(3):343-50.

Mochizuki K, Kondo T, Oishi N, Tahara I, Inoue T, Kasai K, Nakazawa T, Katoh R. Squamous morula formation in colorectal adenoma: Immunohistochemical and molecular analyses. Pathol Res Pract. 2015 Oct;211(10):797-800.

悪性リンパ腫

精巣に発生するびまん性大細胞型B細胞リンパ腫の解析

Molecular genetics of primary testicular diffuse large B-cell lymphoma

精巣に発生するびまん性大細胞型B細胞リンパ腫の解析
代表業績

Oishi N, Kondo T, Nakazawa T, Mochizuki K, Tanioka F, Oyama T, Yamamoto T, Iizuka J, Tanabe K, Shibata N, Kirito K, Katoh R. High prevalence of the MYD88 mutation in testicular lymphoma: Immunohistochemical and genetic analyses. Pathol Int. 2015 Oct;65(10):528-35.


研究業績

2019年

  1. Kuno T, Tsukui Y, Takano S, Maekawa S, Yamaguchi T, Yoshida T, Kobayashi S, Iwamoto F, Ishida Y, Kawakami S, Tanaka K, Fukasawa Y, Muraoka M, Fukasawa M, Shindo H, Inoue T, Nakayama Y, Mochizuki K, Sato T, Enomoto N. Genetic alterations related to endoscopic treatment of colorectal tumors. JGH Open. 2019 Jun 25;4(1):75-82. doi: 10.1002/jgh3.12220. PMID: 32055701; PMCID: PMC7008167.
  2. Kawaida H, Kono H, Amemiya H, Hosomura N, Watanabe M, Saito R, Maruyama S, Shimizu H, Furuya S, Akaike H, Kawaguchi Y, Sudo M, Matusda M, Itakura J, Shindo H, Takahashi EI, Takano S, Fukasawa M, Satou T, Nakazawa T, Enomoto N, Fujii H, Ichikawa D. Stratification of Prognosis in Patients With Ampullary Carcinoma After Surgery by Preoperative Platelet-to-lymphocyte Ratio and Conventional Tumor Markers. Anticancer Res. 2019 Dec;39(12):6923-6929. doi: 10.21873/anticanres.13913. PubMed PMID: 31810963.
  3. Odate T, Vuong HG, Mochizuki K, Oishi N, Kondo T. Assessment of peritoneal elastic laminal invasion improves survival stratification of pT3 and pT4a colorectal cancer: a meta-analysis. J Clin Pathol. 2019 Nov;72(11):736-740. doi: 10.1136/jclinpath-2019-206056. Epub 2019 Aug 30. Review. PubMed PMID: 31471468. 
  4. Omori M, Kondo T, Tagaya H, Watanabe Y, Fukasawa H, Kawai M, Nakazawa K, Hashi A, Hirata S. Utility of imaging modalities for predicting carcinogenesis in lobular endocervical glandular hyperplasia. PLoS One. 2019 Aug 15;14(8):e0221088. doi: 10.1371/journal.pone.0221088. PMID: 31415639; PMCID: PMC6695122.
  5. Takano S, Fukasawa M, Kadokura M, Shindo H, Takahashi E, Hirose S, Fukasawa Y, Kawakami S, Hayakawa H, Maekawa S, Mochizuki K, Kawaida H, Kono H, Itakura J, Sato T, Ichikawa D, Enomoto N. Mutational Patterns in Pancreatic Juice of Intraductal Papillary Mucinous Neoplasms and Concomitant Pancreatic Cancer. Pancreas. 2019 Sep;48(8):1032-1040. doi: 10.1097/MPA.0000000000001371. PMID: 31404021.
  6. Kawai M, Inoue T, Yonaga T, Mochizuki K, Nakazawa T, Masuyama K, Kondo T. Juvenile sclerosing polycystic adenosis cytologically mimicking Warthin tumor. Diagn Cytopathol. 2019 Nov;47(11):1208-1212. doi: 10.1002/dc.24283. Epub 2019 Jul 22. PMID: 31329351.
  7. Luchtel RA, Zimmermann MT, Hu G, Dasari S, Jiang M, Oishi N, Jacobs HK, Zeng Y, Hundal T, Rech KL, Ketterling RP, Lee JH, Eckloff BW, Yan H, Gaonkar KS, Tian S, Ye Z, Kadin ME, Sidhu J, Jiang L, Voss J, Link BK, Syrbu SI, Facchetti F, Bennani NN, Slager SL, Ordog T, Kocher JP, Cerhan JR, Ansell SM, Feldman AL. Recurrent MSC (E116K) mutations in ALK-negative anaplastic large cell lymphoma. Blood. 2019 Jun 27;133(26):2776-2789. doi: 10.1182/blood.2019000626. Epub 2019 May 17. PubMed PMID: 31101622; PubMed Central PMCID: PMC6598380.
  8. Wang J, Kondo T, Nakazawa T, Oishi N, Mochizuki K, Katoh R. Constitutional abnormality of nuclear membrane proteins in small cell lung carcinoma. Virchows Arch. 2019 Oct;475(4):407-414. doi: 10.1007/s00428-019-02597-7. Epub 2019 Jun 15. PubMed PMID: 31201505.
  9. Kawashima I, Fukasawa H, Kasai K, Kumagai T, Koshiishi M, Nakajima K, Kondo T, Hashi A, Hirata S, Kirito K. Bone Marrow Invasion of Small Cell Neuroendocrine Carcinoma of the Endometrium: A Diagnostic Pitfall Mimicking a Haematological Malignancy. Intern Med. 2019 Sep 1;58(17):2561-2568. doi: 10.2169/internalmedicine.2533-18. Epub 2019 May 22. PubMed PMID: 31118384; PubMed Central PMCID: PMC6761356.
  10. Akaishi J, Kondo T, Sugino K, Ogimi Y, Masaki C, Hames KY, Yabuta T, Tomoda C, Suzuki A, Matsuzu K, Uruno T, Ohkuwa K, Kitagawa W, Nagahama M, Katoh R, Ito K. Prognostic Impact of the Turin Criteria in Poorly Differentiated Thyroid Carcinoma. World J Surg. 2019 Sep;43(9):2235-2244. doi: 10.1007/s00268-019-05028-5. PubMed PMID: 31098668.
  11. Nakayama Y, Mimura K, Tamaki T, Shiraishi K, Kua LF, Koh V, Ohmori M, Kimura A, Inoue S, Okayama H, Suzuki Y, Nakazawa T, Ichikawa D, Kono K. Phospho-STAT1 expression as a potential biomarker for anti-PD-1/anti-PD-L1 immunotherapy for breast cancer. Int J Oncol. 2019 Jun;54(6):2030-2038. doi: 10.3892/ijo.2019.4779. Epub 2019 Apr 10. PubMed PMID: 31081058; PubMed Central PMCID: PMC6521934. 
  12. Oishi N, Sartori-Valinotti JC, Bennani NN, Wada DA, He R, Cappel MA, Feldman AL. Cutaneous lesions of angioimmunoblastic T-cell lymphoma: Clinical, pathological, and immunophenotypic features. J Cutan Pathol. 2019 Sep;46(9):637-644. doi: 10.1111/cup.13475. Epub 2019 May 3. PubMed PMID: 30980412.
  13. Yoshida T, Yamaguchi T, Maekawa S, Takano S, Kuno T, Tanaka K, Iwamoto F, Tsukui Y, Kobayashi S, Asakawa Y, Shindo H, Fukasawa M, Nakayama Y, Inoue T, Uetake T, Ohtaka M, Sato T, Mochizuki K, Enomoto N. Identification of early genetic changes in well-differentiated intramucosal gastric carcinoma by target deep sequencing. Gastric Cancer. 2019 Jul;22(4):742-750. doi: 10.1007/s10120-019-00926-y. Epub 2019 Feb 11. PubMed PMID: 30756200.
  14. Matsuoka H, Matsubara H, Sugimura A, Uchida T, Ichihara T, Nakazawa T, Nakajima H. Mesothelial cyst derived from chest wall pleura growing after thoracic surgery: a case report. J Med Case Rep. 2019 Jan 6;13(1):1. doi: 10.1186/s13256-018-1944-0. PubMed PMID: 30611283; PubMed Central PMCID: PMC6321693.
  15. Oishi N, Miranda RN, Feldman AL. Genetics of Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL). Aesthet Surg J. 2019 Jan 31;39(Suppl_1):S14-S20. doi: 10.1093/asj/sjy311. PubMed PMID: 30715169.
  16. Mochizuki K, Hanai Y, Nakazawa K, Murata S, Kasai K, Mochizuki N, Tahara I, Kondo T. IgG4-related disease of the paratestis with the scrotal fluid: A case report. Diagn Cytopathol. 2019 Feb;47(2):130-133. doi: 10.1002/dc.24099. Epub 2018 Oct 30. PubMed PMID: 30375182.
  17. Vuong HG, Ho ATN, Tran TTK, Capdevila J, Benekli M, Nakazawa T, Katoh R, Kondo T. Efficacy and toxicity of sorafenib in the treatment of advanced medullary thyroid carcinoma: A systematic review and meta-analysis. Head Neck. 2019 Aug;41(8):2823-2829. doi: 10.1002/hed.25832. Epub 2019 Jun 4. PMID: 31162772.
  18. Hayakawa H, Fukasawa M, Sato T, Takano S, Kadokura M, Shindo H, Takahashi E, Hirose S, Kawakami S, Fukasawa Y, Maekawa S, Inoue T, Yamaguchi T, Nakayama Y, Kawaida H, Kono H, Mochizuki K, Kondo T, Ichikawa D, Enomoto N. Carcinoembryonic antigen level in the pancreatic juice is effective in malignancy diagnosis and prediction of future malignant transformation of intraductal papillary mucinous neoplasm of the pancreas. J Gastroenterol. 2019 Nov;54(11):1029-1037. doi: 10.1007/s00535-019-01592-8. Epub 2019 May 20. PMID: 31111221.
  19. Vuong HG, Tran TTK, Bychkov A, Jung CK, Nakazawa T, Kakudo K, Katoh R, Kondo T. Clinical Impact Of Non-Invasive Follicular Thyroid Neoplasm With Papillary- Like Nuclear Features On The Risk Of Malignancy In The Bethesda System For Reporting Thyroid Cytopathology: A Meta-Analysis Of 14,153 Resected Thyroid Nodules. Endocr Pract. 2019 May;25(5):491-502. doi: 10.4158/EP-2018-0506. Epub 2019 Jan 18. PMID: 30657357.
  20. Vuong HG, Tran TTK, Ngo HTT, Pham TQ, Nakazawa T, Fung KM, Hassell L, Katoh R, Kondo T. Prognostic significance of genetic biomarkers in isocitrate dehydrogenase-wild-type lower-grade glioma: the need to further stratify this tumor entity - a meta-analysis. Eur J Neurol. 2019 Mar;26(3):379-387. doi: 10.1111/ene.13826. Epub 2018 Nov 13. PMID: 30298540.

2018年

  1. Mochizuki K, Kawai M, Odate T, Tahara I, Inoue T, Kasai K, Nakazawa T, Kondo T. SMARCB1/INI1 Is Diagnostically Useful in Distinguishing α-Fetoprotein-producing Gastric Carcinoma from Hepatocellular Carcinoma. Anticancer Res. 2018 Dec;38(12):6865-6868. doi: 10.21873/anticanres.13061. PubMed PMID: 30504402.
  2. Vuong HG, Long NP, Anh NH, Nghi TD, Hieu MV, Hung LP, Nakazawa T, Katoh R, Kondo T. Papillary thyroid carcinoma with tall cell features is as aggressive as tall cell variant: a meta-analysis. Endocr Connect. 2018 Dec 1;7(12):R286-R293. doi: 10.1530/EC-18-0333. Review. PubMed PMID: 30352403; PubMed Central PMCID:PMC6240142.
  3. Vuong HG, Ho ATN, Altibi AMA, Nakazawa T, Katoh R, Kondo T. Clinicopathological implications of MET exon 14 mutations in non-small cell lung cancer - A systematic review and meta-analysis. Lung Cancer. 2018 Sep;123:76-82. doi: 10.1016/j.lungcan.2018.07.006. Epub 2018 Jul 6. Review. PubMed PMID: 30089599.
  4. Mochizuki K, Kawai M, Odate T, Tahara I, Inoue T, Kasai K, Nakazawa T, Katoh R, Kondo T. Diagnostic Utility of Prostein, Uroplakin II and SATB2 for Diagnosing Carcinoma of Unknown Primary Origin: A Systematic Immunohistochemical Profiling. Anticancer Res. 2018 Aug;38(8):4759-4766. doi: 10.21873/anticanres.12784. PubMed PMID: 30061246.
  5. Omori M, Kondo T, Nakazawa K, Tagaya H, Ohgi M, Fukasawa H, Nakazawa T, Hashi A, Hirata S. Interpretation of Endocervical Cells With Gastric-Type Mucin on Pap Smears: A Proposal for a Cytologic Category "Atypical Endocervical Cells With Gastric-Type Mucin". Am J Clin Pathol. 2018 Jul 5. doi: 10.1093/ajcp/aqy055. [Epub ahead of print] PubMed PMID: 29982289.
  6. Nakazawa T, Kondo T, Vuong HG, Odate T, Kawai M, Tahara I, Kasai K, Inoue T, Oishi N, Mochizuki K, Ito K, Katoh R. High expression of CD10 in anaplastic thyroid carcinomas. Histopathology. 2018 Sep;73(3):492-499. doi: 10.1111/his.13657. Epub 2018 Jun 28. PubMed PMID: 29791034.
  7. Mochizuki K, Kondo T, Oishi N, Tahara I, Inoue T, Kasai K, Nakazawa T, Katoh R. Single-stranded DNA (ssDNA) Labeling Index Is Related to Risk Grade in Patients with Gastrointestinal Stromal Tumors. Anticancer Res. 2018 May;38(5):2939-2943. PubMed PMID: 29715120.
  8. Omori M, Kondo T, Nakazawa K, Shinohara S, Watanabe Y, Fukasawa H, Nakazawa T, Hashi A, Hirata S. A case of endocervical minimal deviation adenocarcinoma with varicolored cytopathologic features on Pap smear. Diagn Cytopathol. 2018 Aug;46(8):702-706. doi: 10.1002/dc.23932. Epub 2018 Mar 23. PubMed PMID: 29573230.
  9. Vuong HG, Odate T, Duong UNP, Mochizuki K, Nakazawa T, Katoh R, Kondo T. Prognostic importance of solid variant papillary thyroid carcinoma: A systematic review and meta-analysis. Head Neck. 2018 Jul;40(7):1588-1597. doi: 10.1002/hed.25123. Epub 2018 Mar 6. Review. PubMed PMID: 29509280.
  10. Masudo K, Suganuma N, Nakayama H, Oshima T, Rino Y, Iwasaki H, Matsuzu K, Sugino K, Ito K, Kondo T, Nakamura Y, Yoshihara M, Masuda M, Miyagi Y. EZH2 Overexpression as a Useful Prognostic Marker for Aggressive Behaviour in Thyroid Cancer. In Vivo. 2018 Jan-Feb;32(1):25-31. PubMed PMID: 29275295; PubMed Central PMCID: PMC5892628.
  11. Morisaka H, Motosugi U, Ichikawa S, Nakazawa T, Kondo T, Funayama S, Matsuda M, Ichikawa T, Onishi H. Magnetic resonance elastography is as accurate as liver biopsy for liver fibrosis staging. J Magn Reson Imaging. 2018 May;47(5):1268-1275. doi: 10.1002/jmri.25868. Epub 2017 Oct 14. PubMed PMID: 29030995.
  12. Vuong HG, Duong UNP, Pham TQ, Tran HM, Oishi N, Mochizuki K, Nakazawa T, Hassell L, Katoh R, Kondo T. Clinicopathological Risk Factors for Distant Metastasis in Differentiated Thyroid Carcinoma: A Meta-analysis. World J Surg. 2018 Apr;42(4):1005-1017. doi: 10.1007/s00268-017-4206-1. Review. PubMed PMID: 28913696.
  13. Luchtel RA, Dasari S, Oishi N, Pedersen MB, Hu G, Rech KL, Ketterling RP, Sidhu J, Wang X, Katoh R, Dogan A, Kip NS, Cunningham JM, Sun Z, Baheti S, Porcher JC, Said JW, Jiang L, Hamilton-Dutoit SJ, Møller MB, Nørgaard P, Bennani NN, Chng WJ, Huang G, Link BK, Facchetti F, Cerhan JR, d'Amore F, Ansell SM, Feldman AL. Molecular profiling reveals immunogenic cues in anaplastic large cell lymphomas with DUSP22 rearrangements. Blood. 2018 Sep 27;132(13):1386-1398. doi: 10.1182/blood-2018-03-838524. Epub 2018 Aug 9. PubMed PMID: 30093402; PubMed Central PMCID: PMC6161771.
  14. Oishi N, Brody GS, Ketterling RP, Viswanatha DS, He R, Dasari S, Mai M, Benson HK, Sattler CA, Boddicker RL, McPhail ED, Bennani NN, Harless CA, Singh K, Clemens MW, Medeiros LJ, Miranda RN, Feldman AL. Genetic subtyping of breast implant-associated anaplastic large cell lymphoma. Blood. 2018 Aug 2;132(5):544-547. doi: 10.1182/blood-2017-12-821868. Epub 2018 Jun 19. PubMed PMID: 29921615; PubMed Central PMCID: PMC6073323.
  15. Sharma A, Oishi N, Boddicker RL, Hu G, Benson HK, Ketterling RP, Greipp PT, Knutson DL, Kloft-Nelson SM, He R, Eckloff BW, Jen J, Nair AA, Davila JI, Dasari S, Lazaridis KN, Bennani NN, Wu TT, Nowakowski GS, Murray JA, Feldman AL. Recurrent STAT3-JAK2 fusions in indolent T-cell lymphoproliferative disorder of the gastrointestinal tract. Blood. 2018 May 17;131(20):2262-2266. doi: 10.1182/blood-2018-01-830968. Epub 2018 Mar 28. PubMed PMID: 29592893; PubMed Central PMCID: PMC5958657.
  16. Oishi N, Montes-Moreno S, Feldman AL. In situ neoplasia in lymph node pathology. Semin Diagn Pathol. 2018 Jan;35(1):76-83. doi: 10.1053/j.semdp.2017.11.001. Epub 2017 Nov 10. Review. PubMed PMID: 29129357.
  17. Kawaida H, Kimura A, Watanabe M, Akaike H, Hosomura N, Kawaguchi Y, Amemiya H, Sudo M, Kono H, Matsuda M, Fujii H, Ichikawa D, Fukasawa M, Takahashi E, Sano K, Inoue T. Successful laparoscopic partial gastrectomy and spleen-preserving distal pancreatectomy for gastric duplication cyst connecting with the pancreatic tail. Int J Surg Case Rep. 2018;44:176-180. doi: 10.1016/j.ijscr.2018.02.028. Epub 2018 Feb 24. PubMed PMID: 29524856; PubMed Central PMCID: PMC5928032.
  18. Akaishi J, Kondo T, Sugino K, Ogimi Y, Masaki C, Hames KY, Yabuta T, Tomoda C, Suzuki A, Matsuzu K, Uruno T, Ohkuwa K, Kitagawa W, Nagahama M, Katoh R, Ito K. Cribriform-Morular Variant of Papillary Thyroid Carcinoma: Clinical and Pathological Features of 30 Cases. World J Surg. 2018 Nov;42(11):3616-3623. doi: 10.1007/s00268-018-4644-4. PubMed PMID: 29696324.
  19. Vuong HG, Odate T, Ngo HTT, Pham TQ, Tran TTK, Mochizuki K, Nakazawa T, Katoh R, Kondo T. Clinical significance of RET and RAS mutations in sporadic medullary thyroid carcinoma: a meta-analysis. Endocr Relat Cancer. 2018 Jun;25(6):633-641. doi: 10.1530/ERC-18-0056. Epub 2018 Apr 3. PMID: 29615431. 
  20. Inoue K, Saito J, Kondo T, Miki K, Sugisawa C, Tsurutani Y, Hasegawa N, Kowase S, Kakuta Y, Omura M, Nishikawa T. Amiodarone-induced Thyrotoxicosis with Cardiopulmonary Arrest. Intern Med. 2018 Jan 1;57(1):59-63. doi: 10.2169/internalmedicine.9177-17. Epub 2017 Oct 16. PMID: 29033440; PMCID: PMC5799058.

2017年

  1. Ashizawa K, Yoshimura K, Johno H, Inoue T, Katoh R, Funayama S, Sakamoto K, Takeda S, Masuyama K, Matsuoka T, Ishii H. Construction of mass spectra database and diagnosis algorithm for head and neck squamous cell carcinoma. Oral Oncol. 2017 Dec;75:111-119. doi: 10.1016/j.oraloncology.2017.11.008. PubMed PMID: 29224807.
  2. Mochizuki K, Kondo T, Oishi N, Tahara I, Inoue T, Kasai K, Nakazawa T, Katoh R. Esophagogastric Junction Carcinomas - Discriminating Histological Types Through Immunohistochemistry. Anticancer Res. 2017 Dec;37(12):6855-6861. PubMed PMID: 29187465.
  3. Takano A, Hirotsu Y, Amemiya K, Nakagomi H, Oishi N, Oyama T, Mochizuki H, Omata M. Genetic basis of a common tumor origin in the development of pancreatic mixed acinar-neuroendocrine-ductal carcinoma: A case report. Oncol Lett. 2017 Oct;14(4):4428-4432. doi: 10.3892/ol.2017.6786. PubMed PMID: 29085438
  4. Vuong HG, Altibi AM, Duong UN, Ngo HT, Pham TQ, Tran HM, Oishi N, Mochizuki K, Nakazawa T, Hassell L, Katoh R, Kondo T. Role of molecular markers to predict distant metastasis in papillary thyroid carcinoma: Promising value of TERT promoter mutations and insignificant role of BRAF mutations-a meta-analysis. Tumour Biol. 2017 Oct;39(10):1010428317713913. doi: 10.1177/1010428317713913. PubMed PMID: 29037127.
  5. Takano S, Fukasawa M, Kadokura M, Shindo H, Takahashi E, Hirose S, Maekawa S, Mochizuki K, Kawaida H, Itakura J, Katoh R, Fujii H, Sato T, Enomoto N. Next-Generation Sequencing Revealed TP53 Mutations to Be Malignant Marker for Intraductal Papillary Mucinous Neoplasms That Could Be Detected Using Pancreatic Juice. Pancreas. 2017 Nov/Dec;46(10):1281-1287. doi: 10.1097/MPA.0000000000000931. PubMed PMID: 28930868.
  6. Morisada T, Teramoto K, Takano H, Sakamoto I, Nishio H, Iwata T, Hashi A, Katoh R, Okamoto A, Sasaki H, Nakatani E, Teramukai S, Aoki D. CITRUS, cervical cancer screening trial by randomization of HPV testing intervention for upcoming screening: Design, methods and baseline data of 18,471 women. Cancer Epidemiol. 2017 Oct;50(Pt A):60-67. doi: 10.1016/j.canep.2017.07.017. PubMed PMID: 28818742.
  7. Oishi N, Kondo T, Ebina A, Sato Y, Akaishi J, Hino R, Yamamoto N, Mochizuki K, Nakazawa T, Yokomichi H, Ito K, Ishikawa Y, Katoh R. Molecular alterations of coexisting thyroid papillary carcinoma and anaplastic carcinoma: identification of TERT mutation as an independent risk factor for transformation. Mod Pathol. 2017 Nov;30(11):1527-1537. doi: 10.1038/modpathol.2017.75. PubMed PMID: 28731042.
  8. Hirokawa M, Miyauchi A, Kihara M, Kudo T, Hashimoto Y, Suzuki S, Daa T, Vuong HG, Mitsutake N. Chromophobe renal cell carcinoma-like thyroid carcinoma: A novel clinicopathologic entity possibly associated with tuberous sclerosis complex. Endocr J. 2017 Sep 30;64(9):843-850. doi: 10.1507/endocrj.EJ17-0096. PubMed PMID: 28680002.
  9. Sakakibara K, Nakajima H, Kasai K. A case of chondrosarcoma originating from the pulmonary artery. Asian Cardiovasc Thorac Ann. 2017 Jun;25(5):398-399. doi: 10.1177/0218492316685243. PubMed PMID: 28673141.
  10. Vuong HG, Kondo T, Oishi N, Nakazawa T, Mochizuki K, Miyauchi A, Hirokawa M, Katoh R. Paediatric follicular thyroid carcinoma - indolent cancer with low prevalence of RAS mutations and absence of PAX8-PPARG fusion in a Japanese population. Histopathology. 2017 Nov;71(5):760-768. doi: 10.1111/his.13285. PubMed PMID: 28621837.
  11. Oh-Oka K, Kojima Y, Uchida K, Yoda K, Ishimaru K, Nakajima S, Hemmi J, Kano H, Fujii-Kuriyama Y, Katoh R, Ito H, Nakao A. Induction of Colonic Regulatory T Cells by Mesalamine by Activating the Aryl Hydrocarbon Receptor. Cell Mol Gastroenterol Hepatol. 2017 Apr 11;4(1):135-151. doi: 10.1016/j.jcmgh.2017.03.010. PubMed PMID: 28593185.
  12. Vuong HG, Kondo T, Duong UNP, Pham TQ, Oishi N, Mochizuki K, Nakazawa T, Hassell L, Katoh R. Prognostic impact of vascular invasion in differentiated thyroid carcinoma: a systematic review and meta-analysis. Eur J Endocrinol. 2017 Aug;177(2):207-216. doi: 10.1530/EJE-17-0260. Review. PubMed PMID: 28566444.
  13. Vuong HG, Kondo T, Pham TQ, Oishi N, Mochizuki K, Nakazawa T, Hassell L, Katoh R. Prognostic significance of diffuse sclerosing variant papillary thyroid carcinoma: a systematic review and meta-analysis. Eur J Endocrinol. 2017 Apr;176(4):431-439. doi: 10.1530/EJE-16-0863. Review. PubMed PMID: 28183787.
  14. Oishi N, Kondo T, Nakazawa T, Mochizuki K, Inoue T, Kasai K, Tahara I, Yabuta T, Hirokawa M, Miyauchi A, Katoh R. Frequent BRAF (V600E) and Absence of TERT Promoter Mutations Characterize Sporadic Pediatric Papillary Thyroid Carcinomas in Japan. Endocr Pathol. 2017 Jun;28(2):103-111. doi: 10.1007/s12022-017-9470-y. PubMed PMID: 28176151.
  15. Vuong HG, Altibi AM, Abdelhamid AH, Ngoc PU, Quan VD, Tantawi MY, Elfil M, Vu TL, Elgebaly A, Oishi N, Nakazawa T, Hirayama K, Katoh R, Huy NT, Kondo T. The changing characteristics and molecular profiles of papillary thyroid carcinoma over time: a systematic review. Oncotarget. 2017 Feb 7;8(6):10637-10649. doi: 10.18632/oncotarget.12885. Review. PubMed PMID: 27793009.

2016年

  1. Luo Y, Akama T, Okayama A, Yoshihara A, Sue M, Oda K, Hayashi M, Ishido Y, Hirano H, Hiroi N, Katoh R, Suzuki K. A Novel Role for Flotillin-Containing Lipid Rafts in Negative-Feedback Regulation of Thyroid-Specific Gene Expression by Thyroglobulin. Thyroid. 2016 Nov;26(11):1630-1639. PubMed PMID: 27676653.
  2. Vuong HG, Kondo T, Oishi N, Nakazawa T, Mochizuki K, Inoue T, Tahara I, Kasai K, Hirokawa M, Tran TM, Katoh R. Genetic alterations of differentiated thyroid carcinoma in iodine-rich and iodine-deficient countries. Cancer Med. 2016 Aug;5(8):1883-9. doi: 10.1002/cam4.781. PubMed PMID: 27264674; PubMed Central PMCID: PMC4898973.
  3. Oishi N, Kondo T, Vuong HG, Nakazawa T, Mochizuki K, Kasai K, Inoue T, Tahara I, Hirokawa M, Miyauchi A, Katoh R. Immunohistochemical detection of NRAS(Q61R) protein in follicular-patterned thyroid tumors. Hum Pathol. 2016 Jul;53:51-7. doi: 10.1016/j.humpath.2016.02.008. PubMed PMID: 26980032.
  4. Omori M, Oishi N, Nakazawa T, Nakazawa K, Mitsumori T, Yuminamochi T, Kirito K, Hirata S. Extranodal NK/T-cell lymphoma, nasal type of the uterine cervix: A case report. Diagn Cytopathol. 2016 May;44(5):430-3. doi: 10.1002/dc.23439. PubMed PMID: 26872300.
  5. Kasajima A, Cameselle-Teijeiro J, Loidi L, Takahashi Y, Nakashima N, Sato S, Fujishima F, Watanabe M, Nakazawa T, Naganuma H, Kondo T, Kato R, Sasano H. A Calcitonin Non-producing Neuroendocrine Tumor of the Thyroid Gland. Endocr Pathol. 2016 Dec;27(4):325-331. PubMed PMID: 26860935.
  6. Vuong HG, Kondo T, Tran TM, Oishi N, Nakazawa T, Mochizuki K, Inoue T, Kasai K, Tahara I, Jieying W, Katoh R. Spindle cell oncocytoma of adenohypophysis: Report of a case and immunohistochemical review of literature. Pathol Res Pract. 2016 Mar;212(3):222-5. doi: 10.1016/j.prp.2015.07.014. Review. PubMed PMID: 26839157.
  7. Nakamura Y, Nakano N, Ishimaru K, Ando N, Katoh R, Suzuki-Inoue K, Koyanagki S, Ogawa H, Okumura K, Shibata S, Nakao A. Inhibition of IgE-mediated allergic reactions by pharmacologically targeting the circadian clock. J Allergy Clin Immunol. 2016 Apr;137(4):1226-35. doi: 10.1016/j.jaci.2015.08.052. PubMed PMID: 26559325.

2. 2015

  1. Nakazawa T, Kondo T, Oishi N, Tahara I, Kasai K, Inoue T, Mochizuki K, Katoh R. Branchial Cleft-Like Cysts Involving 3 Different Organs: Thyroid Gland, Thymus, and Parotid Gland. Medicine (Baltimore). 2015 Oct;94(42):e1758. doi: 10.1097/MD.0000000000001758. PubMed PMID: 26496296; PubMed Central PMCID: PMC4620827.
  2. Oishi N, Kondo T, Nakazawa T, Mochizuki K, Tanioka F, Oyama T, Yamamoto T, Iizuka J, Tanabe K, Shibata N, Kirito K, Katoh R. High prevalence of the MYD88 mutation in testicular lymphoma: Immunohistochemical and genetic analyses. Pathol Int. 2015 Oct;65(10):528-35. doi: 10.1111/pin.12336. PubMed PMID: 26388135.
  3. Mochizuki K, Kondo T, Oishi N, Tahara I, Inoue T, Kasai K, Nakazawa T, Katoh R. Squamous morula formation in colorectal adenoma: Immunohistochemical and molecular analyses. Pathol Res Pract. 2015 Oct;211(10):797-800. doi: 10.1016/j.prp.2015.05.002. PubMed PMID: 26298635.
  4. Mochizuki K, Kondo T, Tahara I, Inoue T, Kasai K, Oishi N, Nakazawa T, Katoh R. Signet ring cell carcinoma of the non-ampullary duodenum: A case report. Pathol Res Pract. 2015 Oct;211(10):801-4. doi: 10.1016/j.prp.2015.04.013. PubMed PMID: 26298633.
  5. Nakazawa T, Kondo T, Sato E, Motosugi U, Niu D, Mochizuki K, Kawasaki T, Yamane T, Katoh R. Subcutaneous porocarcinoma clinically presenting as a soft tissue tumor. J Cutan Pathol. 2015 Nov;42(11):897-902. doi: 10.1111/cup.12576. PubMed PMID: 26268396.
  6. Wang J, Kondo T, Yamane T, Nakazawa T, Oish N, Mochizuki K, Katoh R. Expression of nuclear membrane proteins in normal, hyperplastic, and neoplastic thyroid epithelial cells. Virchows Arch. 2015 Oct;467(4):427-36. doi: 10.1007/s00428-015-1816-6. PubMed PMID: 26254781.
  7. Nakazawa T, Kondo T, Tahara I, Kasai K, Inoue T, Oishi N, Mochizuki K, Kubota T, Katoh R. Multicentric occurrence of multiple papillary thyroid carcinomas--HUMARA and BRAF mutation analysis. Cancer Med. 2015 Aug;4(8):1272-80. doi: 10.1002/cam4.466. PubMed PMID: 25882744; PubMed Central PMCID: PMC4559038.
  8. Kakudo K, Kameyama K, Hirokawa M, Katoh R, Nakamura H. Subclassification of follicular neoplasms recommended by the Japan thyroid association reporting system of thyroid cytology. Int J Endocrinol. 2015;2015:938305. doi: 10.1155/2015/938305. PubMed PMID: 25722720; PubMed Central PMCID: PMC4334867.
  9. Mochizuki K, Kondo T, Oishi N, Tahara I, Inoue T, Kasai K, Nakazawa T, Okamoto T, Shibata N, Katoh R. Low frequency of PAX8-PPARγ rearrangement in follicular thyroid carcinomas in Japanese patients. Pathol Int. 2015 May;65(5):250-3. doi: 10.1111/pin.12270. PubMed PMID: 25708358.
  10. Omori M, Hashi A, Kondo T, Katoh R, Hirata S. Dysregulation of CDK inhibitors and p53 in HPV-negative endocervical adenocarcinoma. Int J Gynecol Pathol. 2015 Mar;34(2):196-203. doi: 10.1097/PGP.0000000000000121. PubMed PMID: 25675191.
  11. Omori M, Kondo T, Yuminamochi T, Nakazawa K, Ishii Y, Fukasawa H, Hashi A, Hirata S. Cytologic features of ovarian granulosa cell tumors in pleural and ascitic fluids. Diagn Cytopathol. 2015 Jul;43(7):581-4. doi: 10.1002/dc.23248. PubMed PMID: 25605680.
  12. Mochizuki K, Kondo T, Tahara I, Inoue T, Kasai K, Oishi N, Nakazawa T, Komiyama A, Katoh R. Gastric adenocarcinoma of pyloric gland type with high-grade malignancy. Pathol Int. 2015 Mar;65(3):148-50. doi: 10.1111/pin.12241. PubMed PMID: 25522773.

3. 2014

  1. Ishii H, Saitoh M, Sakamoto K, Kondo T, Katoh R, Tanaka S, Motizuki M, Masuyama K, Miyazawa K. Epithelial splicing regulatory proteins 1 (ESRP1) and 2 (ESRP2) suppress cancer cell motility via different mechanisms. J Biol Chem. 2014 Oct 3;289(40):27386-99. doi: 10.1074/jbc.M114.589432. PubMed PMID: 25143390; PubMed Central PMCID: PMC4183779.
  2. Oishi N, Kondo T, Nakazawa T, Mochizuki K, Kasai K, Inoue T, Yamamoto T, Watanabe H, Hatsushika K, Masuyama K, Katoh R. Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma: case report and literature review. Pathol Res Pract. 2014 Dec;210(12):1142-5. doi: 10.1016/j.prp.2014.04.020. Review. PubMed PMID: 24893893.
  3. Yamanishi T, Sakamoto K, Watanabe H, Yonaga T, Oishi N, Katoh R, Masuyama K. Primary cervical leiomyoma with remarkable calcification and ossification. Case Rep Otolaryngol. 2014;2014:896275. doi: 10.1155/2014/896275. PubMed PMID: 24711950; PubMed Central PMCID: PMC3965914.
  4. Oishi N, Kondo T, Mochizuki K, Inoue T, Kasai K, Nakazawa T, Mitsumori T, Katoh R. Localized Langerhans cell histiocytosis of the thymus with BRAF V600E mutation: a case report with immunohistochemical and genetic analyses. Hum Pathol. 2014 Jun;45(6):1302-5. doi: 10.1016/j.humpath.2013.12.018. PubMed PMID: 24703101.
  5. Nakazawa T, Cameselle-Teijeiro J, Vinagre J, Soares P, Rousseau E, Eloy C, Sobrinho-Simões M. C-cell-derived calcitonin-free neuroendocrine carcinoma of the thyroid: the diagnostic importance of CGRP immunoreactivity. Int J Surg Pathol. 2014 Sep;22(6):530-5. doi: 10.1177/1066896914525228. PubMed PMID: 24599901.
  6. Omori M, Hashi A, Kondo T, Tagaya H, Hirata S. Successful neoadjuvant chemotherapy for large cell neuroendocrine carcinoma of the cervix: A case report. Gynecol Oncol Case Rep. 2013 Dec 28;8:4-6. doi: 10.1016/j.gynor.2013.12.001. PubMed PMID: 24567884; PubMed Central PMCID: PMC3930816.
  7. Jieying W, Kondo T, Yamane T, Nakazawa T, Oishi N, Kawasaki T, Mochizuki K, Dongfeng N, Katoh R. Heterogeneous Immunoreactivity of Emerin, a Nuclear Envelope LEM-domain Protein, in Normal Thyroid Follicles. Acta Histochem Cytochem. 2014;47(6):289-94. doi: 10.1267/ahc.14041. PubMed PMID: 25859062; PubMed Central PMCID: PMC4387265.
  8. Kawasaki T, Bussolati G, Marchiò C, Castellano I, Daniele L, Molinaro L, Hinata M, Furuya K, Nakagomi H, Oyama T, Tsunoda H, Sugai T, Katoh R, Sapino A. Well-differentiated neuroendocrine tumour of the breast showing peculiar endovascular spread. Histopathology. 2014 Mar;64(4):597-600. doi: 10.1111/his.12276. PubMed PMID: 24215290.
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